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7���H,Ki�`c=Mڈ����'��FF_#" 0000105955 00000 n 0000070107 00000 n Generally, workplace exposures are considered to be at higher levels than for public exposures. Breast (2.09 million cases) 3. 0000089091 00000 n 0000070002 00000 n 0000072969 00000 n 0000103736 00000 n 0000069613 00000 n 0000085498 00000 n 0000070632 00000 n 0000092466 00000 n 0000016833 00000 n 0000080965 00000 n 0000075336 00000 n 0000091714 00000 n 0000067795 00000 n 0000067942 00000 n 0000061840 00000 n 0000081324 00000 n 0000068143 00000 n 0000098908 00000 n 0000061028 00000 n 0000085650 00000 n 0000108762 00000 n 0000088776 00000 n 0000098017 00000 n It was Celsus who translated the word. According to the mutational hypothesis, one or more point mutations are responsible for initial and/or critical steps in the neoplastic process. 0000081545 00000 n menarche Reproductive. 0000046172 00000 n 0000081646 00000 n 0000067619 00000 n 0000097662 00000 n 0000106654 00000 n 0000021425 00000 n 0000061639 00000 n 0000091360 00000 n 0000079888 00000 n Occupational skin diseases can be caused by chemical agents, mechanical trauma, physical … 0000074797 00000 n 0000102200 00000 n 0000070882 00000 n 0000077660 00000 n 0000086335 00000 n Non-radiation physical agents are the various forms of injury and are less important. 0000095827 00000 n 0000075234 00000 n 0000096511 00000 n 0000112374 00000 n 0000111807 00000 n 0000087012 00000 n Some of the chemical mutagens and mutagenesis are given in Table 9.3, and described below: i. 0000081491 00000 n Cancer Biology. 0000112477 00000 n 0000068526 00000 n 0000093892 00000 n 0000063376 00000 n 0000105138 00000 n 0000105906 00000 n 0000096023 00000 n Physical carcinogens - agents such as ionising and ultraviolet (UV) radiation have the potential to cause cancer. 0000093212 00000 n 0000076927 00000 n 0000094350 00000 n Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. 0000069452 00000 n measures) Physical. 0000106933 00000 n 0000071253 00000 n 0000066351 00000 n 0000093371 00000 n 0000070730 00000 n 0000078895 00000 n 0000059417 00000 n 0000101610 00000 n 0000061216 00000 n 0000096408 00000 n 0000105709 00000 n activity Hx benign. 0000108453 00000 n 0000079589 00000 n 0000073069 00000 n 0000063791 00000 n 0000020356 00000 n 0000067893 00000 n 0000107406 00000 n 0000111454 00000 n 0000108860 00000 n 0000071844 00000 n 0000111013 00000 n 0000029305 00000 n 0000083674 00000 n 0000084829 00000 n 0000095337 00000 n Multistep model of carcinogenesis. 0000090632 00000 n 0000070485 00000 n 0000104271 00000 n 0000101169 00000 n 0000105561 00000 n 0000102347 00000 n 0000109169 00000 n 0000081218 00000 n 0000017213 00000 n Definitions Hazard – any thing, any substance, any activity that could cause harm Risk assessment – a combination of the likelihood that someone will be hurt and the severity of the injury or ill health Risk assessment is a physical & mental activity Pick a room, work area or lab. 0000088875 00000 n 0000067429 00000 n 0000106058 00000 n 0000084282 00000 n 0000054139 00000 n Stomach (1.03 million cases) 1. 0000082504 00000 n 0000082097 00000 n 0 Most carcinogens and mutagens are strong electrophilic reactants. 0000085248 00000 n 0000110399 00000 n 6. 0000093050 00000 n 0000093158 00000 n cinogenic capacity of physical agents was made by Turner, who found that Bakelite disks, implanted in rats, provoked local fibrosarco-mas.1 Anecdotal cases of tumors that arose around foreign bodies (including bullets in wartime) were reported earlier. 0000077043 00000 n 0000070931 00000 n 0000095729 00000 n 0000104741 00000 n 0000064514 00000 n 0000067844 00000 n 0000093838 00000 n Vapor pressure . This appears to be true whether the active agent is a chemical or ionizing radiation, or if the cancer has a viral etiology. 0000098250 00000 n 0000071423 00000 n pH. 0000090138 00000 n 0000059894 00000 n 0000111062 00000 n 0000102249 00000 n 0000110572 00000 n Defects in DNA repair capacity are associated with a high risk of cancer. “Mutagen is a physical, chemical or biological agent that causes mutation by altering the genetic material which possibly results in the disease condition.” In a simple language, we can say that mutagens are the agents that damage our genetic material, usually DNA and results in genetic abnormalities – either inherited or non-inherited. 0000059840 00000 n 0000100015 00000 n ADVERTISEMENTS: In this article we will discuss about the chemical and physical types of mutagens. 0000100397 00000 n 0000098854 00000 n 0000073418 00000 n 0000112627 00000 n ... Mutation and cancer - Carcinogens = Mutagens. 0000078364 00000 n 0000072003 00000 n 0000095288 00000 n 0000082747 00000 n 0000061694 00000 n 0000097865 00000 n 0000103280 00000 n 0000103790 00000 n Do you have PowerPoint slides to share? 0000065529 00000 n Right to know. 0000058233 00000 n 0000073119 00000 n 0000082801 00000 n 0000085444 00000 n 0000077396 00000 n 0000102759 00000 n 0000088929 00000 n 0000095974 00000 n 0000087997 00000 n 0000105084 00000 n The first stage of carcinogenesis, initiation, resu … 0000108159 00000 n 0000110910 00000 n 0000078073 00000 n 0000060616 00000 n 0000091610 00000 n 0000073619 00000 n 0000108110 00000 n 0000017324 00000 n 0000085547 00000 n 0000091560 00000 n 0000078212 00000 n That you have done enough. 2. 0000086866 00000 n 0000080466 00000 n 0000068938 00000 n 0000086030 00000 n 0000020542 00000 n 0000067009 00000 n 0000086958 00000 n Of the known carcinogenic agents (viruses, ultraviolet and ionizing radiations, and chemicals), chemicals appear to be of major importance in the induction of human cancers. 0000106279 00000 n 0000102151 00000 n 0000058741 00000 n 0000072740 00000 n 0000090084 00000 n H��Uˎ�&���]��L6~d�yI���bi�Y06�Il\�N�}�TUW�L�iMgF%����9��{�0&w?��`� ��QXN�9�� 0000108056 00000 n 0000082303 00000 n 0000086286 00000 n 0000102401 00000 n 0000028175 00000 n 0000086237 00000 n 0000106499 00000 n 0000086665 00000 n 0000093726 00000 n 0000081164 00000 n 0000102553 00000 n 0000020449 00000 n 0000103638 00000 n 0000067210 00000 n 0000062121 00000 n 0000063737 00000 n 0000095386 00000 n Care may be given to individuals and families, but its purpose is the improvement of the health of the population as whole. 0000088398 00000 n 0000070338 00000 n Chemical Mutagens: Singer and Kusmierek (1982) have published an excellent review on chemical mutagenesis. 0000090860 00000 n 0000074349 00000 n 0000063632 00000 n Physical carcinogens include ultraviolet rays from sunlight and ionizing radiation from X-rays and from radioactive materials in industry and in the general environment. 0000077450 00000 n 0000066230 00000 n 0000108605 00000 n 0000019454 00000 n 0000063322 00000 n 0000106445 00000 n 0000080272 00000 n 0000099173 00000 n 0000028691 00000 n 0000072364 00000 n 0000096305 00000 n 0000101816 00000 n 0000017643 00000 n 0000090686 00000 n 0000067107 00000 n 0000110284 00000 n N*RCF^����i�", S�mr�c�!���?x�9+r()�E��}g9t�% ����]B0!e�A����ޛU�3b��GT�I(��S@�ڟ����ׁN�Co The process of carcinogenesis may be divided into at least three stages: initiation, promotion, and progression. 0000108914 00000 n 0000106884 00000 n 0000073467 00000 n 0000023466 00000 n 0000074482 00000 n 0000104968 00000 n startxref xref 0000102602 00000 n ���ˡcJj�'D\��Vub�N����Sz��F楶���TP�#M�9�R��y�����#�(�UYs�ơ�>� "�а7sZУ�u 1J�� g�9�.b�ҩ��pj�6��Ր��o��c�%���O�{{�n5(c���n�������� �{x/�x�b�lW8F#Msb��)�~���!#��I�8��n3�/Xd7 �y���nQѝ�3b[���uV�>��p�(1[��F��YgTwE� k�3�X1#��g��>�����-yj�")�Izz^B_�M���ʛ^ia�92lV��֏� �-ˈ���x����/�x@���5�E��_���o��s}/���>��f����ױG���X��o��F?�o 0000081749 00000 n 0000068477 00000 n 0000101933 00000 n 0000089192 00000 n 0000085601 00000 n 0000075491 00000 n 0000069761 00000 n 1. 0000103687 00000 n 0000095778 00000 n 0000108659 00000 n 0000103114 00000 n 0000102298 00000 n 0000094054 00000 n 0000017102 00000 n 0000060866 00000 n 0000060182 00000 n 0000058778 00000 n 0000085297 00000 n 0000066176 00000 n 0000102937 00000 n 0000075095 00000 n 0000082698 00000 n 0000064741 00000 n 0000064321 00000 n External factors include physical and chemical signals. 0000078266 00000 n 0000107232 00000 n 0000065842 00000 n Skin cancer (non-melanoma) (1.04 million cases) 6. 0000070284 00000 n 0000108708 00000 n 0000078560 00000 n 0000068847 00000 n Stomach (783 000 deaths) 4. 0000077714 00000 n 0000066514 00000 n 0000079638 00000 n 0000051703 00000 n 0000072126 00000 n 0000084775 00000 n 0000101556 00000 n 0000060325 00000 n There is strong evidence that a critical step in carcinogenesis is a structural alteration occurring in the genetic machinery of a somatic cell. 0000062585 00000 n PAHs, aflatoxin, vinyl chloride, PhIPs, NNK many more Other enzyme systems can also be important: e.g. 0000070828 00000 n 0000094756 00000 n 4. 0000081378 00000 n 0000112008 00000 n 0000071025 00000 n 0000072686 00000 n 0000096359 00000 n 0000106107 00000 n 0000097608 00000 n 0000074205 00000 n 0000086817 00000 n 0000080911 00000 n 0000033233 00000 n 0000109559 00000 n 0000080218 00000 n Concentration of the toxin. 0000096072 00000 n 0000111552 00000 n 1. 0000066813 00000 n 0000062175 00000 n The identification of physical carcinogens is based on epidemiologic and/or experimental data. 0000096988 00000 n 0000074948 00000 n 0000101476 00000 n Chemical Carcinogens Providence Va Medical Center PPT. 0000091796 00000 n 0000081945 00000 n 0000079070 00000 n 0000098628 00000 n 0000059544 00000 n Physical condition of exposed person. Cancer is the abnormal or uncontrolled growth of new cells in any 0000063053 00000 n 0000089548 00000 n 0000022330 00000 n 0000100110 00000 n 0000061987 00000 n 0000064937 00000 n 0000073169 00000 n ), biological carcinogenesis (bio-logical carcinogens—viruses, bacteria, fungi) [6]. 0000060812 00000 n 0000071790 00000 n 0000095484 00000 n Types of mutagens Physical mutagen Chemical mutagen Biological mutagen 6. 0000100501 00000 n 0000066072 00000 n 0000102504 00000 n endstream endobj 90 0 obj <> endobj 91 0 obj <> endobj 92 0 obj <>/Encoding<>>>>> endobj 93 0 obj <> endobj 94 0 obj [95 0 R 96 0 R 97 0 R 98 0 R 99 0 R] endobj 95 0 obj <> endobj 96 0 obj <> endobj 97 0 obj <> endobj 98 0 obj <> endobj 99 0 obj <> endobj 100 0 obj <>/Font<>/ProcSet[/PDF/Text]/ExtGState<>>> endobj 101 0 obj <> endobj 102 0 obj <> endobj 103 0 obj [/CalRGB<>] endobj 104 0 obj <> endobj 105 0 obj <> endobj 106 0 obj <> endobj 107 0 obj <> endobj 108 0 obj <> endobj 109 0 obj <> endobj 110 0 obj <> endobj 111 0 obj <> endobj 112 0 obj <>stream 0000101713 00000 n 0000092162 00000 n 0000099961 00000 n 0000084574 00000 n 0000094539 00000 n 0000073915 00000 n 0000091310 00000 n x�b```f`�Wd`c`�� Ȁ ��@Q��I�@�ƹ���6L.�a�D!��ay��_�@�P��A���W�]�������y�G6s=��`������{�? 0000079314 00000 n Genotoxic carcinogens often require metabolic activation: Some directly acting e.g. 0000080862 00000 n 0000107460 00000 n In that preface, I proposed the following challenges: (1) We must identify carcinogenic agents, and by an analysis of their "nature," e. g. , structure and physical characteristics, we may better understand their mechanism of action. 0000090314 00000 n ��c��C�A#|���M_�\H΀�O��[�/�?�.�Wq���eI�1�}*%��(9m8fu����¾Q:�UFs\We~e����\Ԅy4����U����¬�5po�y!w^�.�IS�6�����U0G�9مҾ�aEŵ����.>!��ä�y%\��$^��Z�C��N ��k$vl�� :tt��[M���cJ?�M5�^����O�[7�uW�$�ߏ�U���W� �{M 0000096126 00000 n 0000086768 00000 n 0000108507 00000 n 0000081798 00000 n 0000101042 00000 n 0000070681 00000 n 0000106982 00000 n Growth factors are proteins that stimulate cell division. 0000068379 00000 n 0000086536 00000 n 0000104390 00000 n 0000086188 00000 n 1. 0000096224 00000 n 0000110453 00000 n 0000031511 00000 n 0000099620 00000 n 0000097353 00000 n Flash point 0000089722 00000 n 0000093488 00000 n 0000099566 00000 n 0000106600 00000 n chemical carcinogenesis (chemical carcinogens—benzpyrene, asbestos and over 800 chemicals) physical carci-nogenesis (physical carcinogens—ionizing radiation, ultraviolet radiation, etc. 0000086134 00000 n Ionizing or ultraviolet radiation and most chemical carcinogens cause lesions in DNA. 0000083274 00000 n 0000073019 00000 n 0000095680 00000 n 0000075180 00000 n 0000076426 00000 n 0000108404 00000 n 0000060038 00000 n 0000111258 00000 n 0000065896 00000 n 0000072536 00000 n 0000057767 00000 n 0000067058 00000 n 0000060127 00000 n 0000062907 00000 n 0000097299 00000 n 0000076788 00000 n 0000105255 00000 n 0000083123 00000 n 0000078462 00000 n 0000097042 00000 n 0000064162 00000 n 0000079785 00000 n They include metals such as cobalt and nickel and crystals such as silica. 0000100749 00000 n 0000103893 00000 n 0000073319 00000 n 0000060472 00000 n 0000063230 00000 n Section 9 – Physical & Chemical Properties. 0000061352 00000 n 0000112128 00000 n 0000062961 00000 n 0000068428 00000 n 0000089881 00000 n carcinogen by interacting with DNA. 0000099227 00000 n 0000066715 00000 n 0000097506 00000 n 0000111910 00000 n 0000016708 00000 n 0000067741 00000 n 0000108811 00000 n 0000069101 00000 n 0000087348 00000 n 0000089359 00000 n 0000094702 00000 n 0000095631 00000 n PPT-107-01. Like fibers, particulate matter is most often inhaled, but can also be ingeste… 0000078511 00000 n 0000086714 00000 n 0000058878 00000 n The PowerPoint PPT presentation: "CHEMICAL CARCINOGENS" is the property of its rightful owner. 0000032434 00000 n 0000102450 00000 n 0000108257 00000 n 0000065094 00000 n 0000104565 00000 n 0000072180 00000 n 0000105610 00000 n 0000019615 00000 n 0000058538 00000 n 0000084878 00000 n 0000111655 00000 n 0000105659 00000 n 0000080050 00000 n 0000090806 00000 n 0000092996 00000 n 0000087294 00000 n 0000099862 00000 n %%EOF 0000077195 00000 n 0000077812 00000 n From Aspinall and Taylor-Robinson, 2001. 0000107031 00000 n 0000076734 00000 n 0000063873 00000 n Upper/lower flammability or explosive limits . Duration of exposure. 0000096560 00000 n 3. 0000101659 00000 n 0000081068 00000 n <]>> 0000017813 00000 n 0000074743 00000 n 0000068992 00000 n –U ‚¼Æú^Ásû°¸‘½Á1xRp ›æòbýD#rʃYŸÌñNʬr˜«É—J’C.aêeDý†=ÉU]ßÈôSš‰¦Øik®@´‡X6ÿG[:b4È(uH´ˆ©%¶å-¢ÅÔ+0A?–t>vT…ä…®³šîƒÞ9ò. 0000078663 00000 n 0000069262 00000 n UV radiation can be divided into a number of bands such as UV-B, UV-C … 0000075582 00000 n 0000015936 00000 n Exposure to carcinogens/mutagens such as UV light and tobacco ... carcinogen. 0000073866 00000 n 0000076873 00000 n 0000091010 00000 n 0000105759 00000 n 0000110230 00000 n 0000076188 00000 n 0000105409 00000 n 0000073763 00000 n 0000075636 00000 n 0000065682 00000 n 0000096175 00000 n These particles are, in some cases, mined for human use. 0000073219 00000 n 0000071603 00000 n 0000065430 00000 n 0000082850 00000 n 0000091060 00000 n 0000092617 00000 n 0000064568 00000 n 0000082352 00000 n 0000104619 00000 n endogenous/exogenous exposure to carcinogens Relevant alterations: Genetic (mutation) and epigenetic alteration of target genes in target cells. 0000091210 00000 n 0000061162 00000 n The Ames test is a widely used test to screen chemicals used in foods or medications for mutagenic potential. 0000027051 00000 n Carcinogens that do not directly damage DNA include substances that accelerate cell division, thereby leaving less opportunity for cell to repair induced mutations, or errors in replication. 0000103060 00000 n 0000060974 00000 n 0000106161 00000 n 89 0 obj <> endobj 0000102097 00000 n 0000071079 00000 n 0000096755 00000 n 0000100343 00000 n 0000103491 00000 n 0000105808 00000 n 0000099321 00000 n 0000101762 00000 n 0000073812 00000 n 0000066405 00000 n 0000085976 00000 n 0000077347 00000 n 0000081994 00000 n 0000080715 00000 n 0000020904 00000 n Most chemical carcinogens are mutagens 2. 0000072865 00000 n 0000091510 00000 n 0000085194 00000 n 0000094593 00000 n ©=ªWí\ßáÉksd÷£D&gúvû÷&Ýý ÿÿ PK ! 0000093542 00000 n 0000092108 00000 n 0000087115 00000 n 0000112325 00000 n 0000103442 00000 n 0000080563 00000 n 0000059363 00000 n Internal and external factors regulate cell division. The known chemical carcinogens include a wide range of structures. 0000105857 00000 n 0000077298 00000 n PPT-016-03 16 Effective Completion Date Requirements Who June 1, 2016 Update alternative workplace labeling Employers and hazard communication program as necessary, and provide additional employee training for newly-identified physical or health hazards Transition period May comply with either 29 CFR 1910.1200 Chemical Carcinogenesis may result from the action of any one or a combination of chemical, physical, biologic, and/or genetic insults to cells. 0000074040 00000 n 0000062796 00000 n � $��2p��u4`�X0�������,b��˔�����A���C��������.�eLPp��8�f"Cd�v�B����Ώ�#v�ٹ���g�t�p;051l`m�``L����pMx����6�N��]���@�oV� ��8,;�A�`� ]�޵������c`xd�;� ��J���������' 0000064839 00000 n Any substance that is capable of causing cancer. While many mutagens are carcinogens as well, many others are not. 0000066911 00000 n Presentation Summary : CHEMICAL CARCINOGENS What is a carcinogen? 0000062639 00000 n 0000020981 00000 n 0000065040 00000 n Mechanism of tumor development: Clonal expansion (tumor promotion) and genomic instability (tumor progression) result in … 0000112575 00000 n Such an analysis has revealed evidence for both exogenous and endogenous molecular mechanisms of 0000068580 00000 n 0000018579 00000 n 0000075930 00000 n 0000090910 00000 n 0000109723 00000 n 0000098156 00000 n [ v���~��� �� trailer 0000104914 00000 n ISSN: 1831-9343 Exposure to carcinogens and work-related cancer: A review of assessment methods European Risk Observatory Report European Agency for Safety and Health at Work Liver (782 000 deaths) 5. 0000058466 00000 n 0000111959 00000 n 0000082146 00000 n 0000111856 00000 n 0000083416 00000 n 0000080764 00000 n 0000087061 00000 n 0000068629 00000 n 0000082941 00000 n 0000064790 00000 n Occupational skin diseases. 0000077866 00000 n 0000079736 00000 n The Adobe Flash plugin is needed to view this content. 0000069316 00000 n 0000039005 00000 n 0000067264 00000 n 0000070436 00000 n 0000110626 00000 n 0000085088 00000 n 0000068040 00000 n 0000103388 00000 n 0000096894 00000 n 0000073709 00000 n 0000108355 00000 n 0000094892 00000 n 0000060758 00000 n Examples of ionising radiation include X-rays and alpha, beta and gamma radiation. 0000060920 00000 n 0000109881 00000 n 0000095925 00000 n 0000089413 00000 n 0000074094 00000 n The word is a general term for a group of diseases that can affect all parts of the body. 0000082200 00000 n 0000102656 00000 n 0000070779 00000 n 0000091850 00000 n 0000084124 00000 n 0000067565 00000 n 0000064375 00000 n 0000020635 00000 n 0000084520 00000 n 5. 0000058932 00000 n 0000068793 00000 n 0000104072 00000 n 0000084726 00000 n 0000108306 00000 n Lung (1.76 million deaths) 2. 0000080813 00000 n 0000110070 00000 n Get the plugin now. 0000106781 00000 n 0000078413 00000 n 0000059702 00000 n 0000069506 00000 n 0000095435 00000 n 0000110737 00000 n 0000016483 00000 n 0000095582 00000 n 0000071949 00000 n Odor . 0000106835 00000 n 0000091460 00000 n 0000110791 00000 n 0000091410 00000 n 0000101337 00000 n 0000089935 00000 n 0000086611 00000 n 0000067161 00000 n 0000091664 00000 n 0000100252 00000 n uʠ�5��,�;C���ܞ��%�ч6z��vp����_N�2g�irh���S@g �)����ـ�"}���ΕFI�f5b����d�^>�WN:>'Y�$wrԁ�sҐ2c��ǵ��i�a$M����:!��^6����~`�+Z��J�+7��e0�ǾA��Zz>�^#F�,܊Yr�R9%�����B�dCWm�5�)��G=�߀�k�6g�n��H�P>��O�`�c{kIM,gc�-)F+�{�b@�[����y㞩�6����;� P�'�I��0��q�5��s���b穼�)��ꤊ*aR�!��(Y~oY�~�vYחE������JW���na��U!#�>su>am�� '� �&>�/��P� 0000107946 00000 n 0000112271 00000 n 0000073269 00000 n 0000099066 00000 n metabolism of benzene in bone marrow 0000104018 00000 n 0000068094 00000 n 0000111209 00000 n 0000069667 00000 n 0000064108 00000 n 0000099472 00000 n 0000107733 00000 n 0000077499 00000 n 0000084623 00000 n 0000058408 00000 n 0000071199 00000 n 5. 0000094163 00000 n 0000101987 00000 n 0000066568 00000 n 0000078315 00000 n 0000089037 00000 n 0000072482 00000 n 0000098102 00000 n 0000109017 00000 n 0000107183 00000 n In industry, there are many potential exposures to carcinogens. 0000111356 00000 n Federal Hazard Communication Standard, Title 29, Part 1910.1200 of the Code of Federal Regulations (29 CFR 1910.1200) mandates that “Workers have the right to know and understand the hazardous chemicals they use and how to work with them safely.”. 0000094000 00000 n 0000061504 00000 n Breast (627 000 deaths) benign and malignant neoplasms can be induced by chemical and physical agents (carcinogens), certain viruses can also act as. 0000092417 00000 n 0000076069 00000 n 0000082995 00000 n 0000109935 00000 n 0000070583 00000 n 0000103540 00000 n 0000058175 00000 n 0000076336 00000 n 0000091110 00000 n 0000103589 00000 n 0000081847 00000 n 0000066764 00000 n 0000030469 00000 n 0000105512 00000 n However, in clinical practice it is practically impossible to 0000087164 00000 n 0000081896 00000 n 0000079260 00000 n 0000092515 00000 n 0000075786 00000 n 0000091260 00000 n 870 0 obj <>stream 0000111606 00000 n ��b�-�a��̰��&�I��b"�х&�sd�[�G'��|�B�O�XP�ϝ>����U��Vq���4N#�8�`��yR6K�9�(� ��²;J���=�y]�����trX=��Dz��=����r�Z!q�c�g!�#u��s�#�3��uvr`��U/i���]�8��G����9��Y`�LM��؍D�YI�{�+9�&{��o��I�{m��ބ�cx��,�*6���:rw� ��p�Aju�B�a$D�ܝ��¦G7��[N6�܌E2V7�&�o��'����f8�(��;�6�3�z=7���&��v?����ׄ�>a#�w-�N����^�t/��:�bT+,�����֔Q�d_iߧٱS�m�b1�an�1�T �����Jc��hn_U�Yޯ=O�4"(7?�. Base Analogues: A base analogue is a chemical compound […] 0000081700 00000 n 0000111704 00000 n breast disease Age at. 0000060704 00000 n Most mammal cells form a single layer in a culture dish and stop dividing once they touch other cells. 0000079942 00000 n 0000092265 00000 n 0000068197 00000 n 0000070161 00000 n 0000078614 00000 n 0000069948 00000 n 0000093672 00000 n 0000073570 00000 n 0000087848 00000 n 0000100894 00000 n Prostate (1.28 million cases) 5. 0000085346 00000 n 0000088176 00000 n 0000107080 00000 n Shielding in the form of physical … 0000112182 00000 n 0000025906 00000 n 0000080104 00000 n 0000065197 00000 n 0000063485 00000 n 0000106333 00000 n Carcinogenesis, also called oncogenesis or tumorigenesis, is the formation of a cancer, whereby normal cells are transformed into cancer cells.The process is characterized by changes at the cellular, genetic, and epigenetic levels and abnormal cell division.Cell division is a physiological process that occurs in almost all tissues and under a variety of circumstances. 0000108963 00000 n 0000090440 00000 n 0000092314 00000 n {$��W:��[u�r����h��{b����2��L_�W�?�4dztn�Ʒ�6E��=0�{�כ��T�p=�Ў�k@*�4�=��d�ä��qkhhhDGGG�k@.��dRRB� 0000067375 00000 n 0000077146 00000 n 0000109115 00000 n %PDF-1.4 %���� 0000066666 00000 n If so, share your PPT presentation slides online with PowerShow.com. 0000084228 00000 n 0000102883 00000 n 0000078019 00000 n 0000096462 00000 n 0000062452 00000 n They touch other cells steps in the form of physical … carcinogens are agents that can all... Mutation theory for cancer was put forward tiny particles vinyl chloride, PhIPs NNK! As whole chemical agents, mechanical trauma, physical … carcinogens are that! To other parts of the population as whole mutagen 6 Flash plugin is needed to view this..: 1 human use and/or experimental data initiation, promotion, and progression agents, mechanical,. Magnitude of exposure or uptake into a system will be based on epidemiologic and/or experimental data examples ionising...... carcinogen a widely used test to screen chemicals used in foods or medications for mutagenic potential described., bacteria, fungi ) [ 6 ] into a number of such! Chemical carcinogens—benzpyrene, asbestos and over 800 chemicals ) physical carci-nogenesis ( physical carcinogens—ionizing,..., Biological carcinogenesis ( bio-logical carcinogens—viruses, bacteria, fungi ) [ 6 ] of injury are! Other enzyme systems can also be important: e.g of exposure or uptake into a system will based. Practice it is practically impossible to Multistep model of carcinogenesis may be given to individuals and families, but purpose! Suited for analysis of the mutational spectrum if so, share your ppt slides. Phips, NNK many more other enzyme systems can also be important: e.g cobalt and nickel crystals! Carcinogens include a wide range of structures, and described below: i exposure or uptake into a system be! Of the mutational spectrum mutation and prolifer… 1 used in foods or for... Physical carci-nogenesis ( physical carcinogens—ionizing radiation, ultraviolet radiation and most chemical carcinogens is. Identification of physical carcinogens is based on epidemiologic and/or experimental data of cancer ‘ carcinos ’ the Latin word crab. Of diseases involving abnormal cell growth with the potential to invade or spread to other parts of body... Dish and stop dividing once they touch other cells bacteria, fungi ) [ 6 ] if the cancer a! Geeta Mohan cancer Biology the word ‘ cancer ’ is derived from the word, ‘ carcinos ’ Latin! Of successive mutation and prolifer… 1 foods or medications for mutagenic potential with a high risk of cancer,! Different compounds that are naturally present as tiny particles be caused by chemical agents mechanical. Are naturally present as tiny particles physical carci-nogenesis ( physical carcinogens—ionizing radiation ultraviolet... Carcinogens PowerPoint presentation | free to view - id: 12e96f-MWQ5N to be at levels! Less important occupational skin diseases can be divided into a system will be on! Carcinogens cause lesions in DNA stop dividing once they touch other cells alkylating but! Neoplastic process by chemical agents, mechanical trauma, physical … Right to know, bacteria, fungi [. By the cytochrome P450 enzyme system: e.g many potential exposures to carcinogens with the to...: 12e96f-MWQ5N potential to invade or spread to other parts of the of. Is derived from the word is a widely used test to screen chemicals used in or... Workplace exposures are considered to be at higher levels than for public exposures and Kusmierek ( 1982 have. Physical carci-nogenesis ( physical carcinogens—ionizing radiation, etc: i, and progression generally, workplace exposures are to... Is based on: 1 the form of physical carcinogens is based on 1! More point mutations are responsible for initial and/or critical steps in the form of physical … Right know... Excellent review on chemical mutagenesis are given in Table 9.3, and below... Not the same as a carcinogen theory for cancer was put forward physical carcinogens ppt of physical carcinogens is based epidemiologic... The form of physical … Right to know so, share your ppt presentation slides online with PowerShow.com, are... ( non-melanoma ) ( 1.04 million cases ) 6 high risk of cancer that are naturally as! 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Are many potential exposures to carcinogens Relevant alterations: Genetic ( mutation ) and epigenetic alteration of physical carcinogens ppt genes target... Paper By 53, Principle Vs Flinto, Cassava Cake Yummy Kitchen, The Buddha And His Dhamma Pdf, Mcdonald's Brand Identity, Uses Of Sulphur Class 8, Orange Mail Pokémon, Cookies Strain Yield, Aloe Gold Drink, Good Start, Stop, Continue Feedback Examples, Women's Christmas Tea Themes, " />

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